Article

Phenylacetyl-CoA, not phenylacetic acid, attenuates CepIR-regulated virulence in <i>Burkholderia cenocepacia</i>

2019-07-13

Abstract excerpt

During phenylalanine catabolism, phenylacetic acid (PAA) is converted to phenylacetyl-CoA (PAA-CoA) by a ligase, PaaK, and then epoxidized by a multicomponent monooxygenase, PaaABCDE, before further degradation to the TCA cycle. In the opportunistic pathogen Burkholderia cenocepacia, loss of paaABCDE attenuates virulence factor expression, which is under control of the LuxIR-like quorum sensing system, CepIR. To...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65bfe77f-0a42-57b6-b460-05ba73ba90e3
DOI: 10.1101/700799

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phenylacetyl-CoA, not phenylacetic acid, attenuates CepIR-regulated virulence in <i>Burkholderia cenocepacia</i>DOI 10.1101/700799Read

A Functional Phenylacetic Acid Catabolic Pathway Is Required for Full Pathogenicity of <i>Burkholderia cenocepacia</i> in the <i>Caenorhabditis elegans</i> Host ModelSemantic proximity Read

A Unique Regulator Contributes to Quorum Sensing and Virulence in Burkholderia cenocepaciaSemantic proximity Read

Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.Semantic proximity Read

Right on Q: Genetics begin to Unravel <i>Coxiella Burnetii</i> host cell InteractionsSemantic proximity Read

Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepaciaSemantic proximity Read

Quorum Sensing in <i>Burkholderia cepacia</i> : Identification of the LuxRI Homologs CepRISemantic proximity Read

The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections.Semantic proximity Read

Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.Semantic proximity Read

A LuxR ‐type repressor of B urkholderia cenocepacia inhibits transcription via antiactivation and is inactivated by its cognate acylhomoserine lactoneSemantic proximity Read

RsaM: a transcriptional regulator of <i><scp>B</scp>urkholderia</i> spp. with novel foldSemantic proximity Read

Phenotypic and genotypic characterisation of Burkholderia cenocepacia J2315 mutants affected in homoserine lactone and diffusible signal factor-based quorum sensing systems suggests interplay between both types of systems.Semantic proximity Read

Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferiSemantic proximity Read