Article

Monoclonal nanobodies alter the activity and assembly of the yeast vacuolar H <sup>+</sup> -ATPase

2025-01-11

Abstract excerpt

The vacuolar ATPase (V-ATPase; V 1 V o ) is a multi-subunit rotary nanomotor proton pump that acidifies organelles in virtually all eukaryotic cells, and extracellular spaces in some specialized tissues of higher organisms. Evidence suggests that metastatic breast cancers mislocalize V-ATPase to the plasma membrane to promote cell survival and facilitate metastasis, making the V-ATPase a potential drug target. W...

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Literature Corpus work: 65abc183-3d53-5bd2-a25b-4f4800a82f75
DOI: 10.1101/2025.01.10.632502

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