Broad-Spectrum HIV-1 Detection and Neutralization via Multivalent Designer DNA Nanostructures

Abstract excerpt

Early and accurate detection of HIV-1 remains a critical unmet need, particularly during the acute phase of infection when viral loads are low and transmission risk is highest. Here, we report a modular diagnostic and antiviral platform based on designer DNA nanostructures engineered for high-affinity recognition of the HIV-1 envelope glycoprotein (GP120). A custom DNA aptamer, termed HINT, was developed to bind G...

Topics

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• Advanced biosensing and bioanalysis techniques
• CRISPR and Genetic Engineering
• DNA
• Mutation
• Nucleic Acid Hybridization
• Nucleic Acids
• Oligonucleotide Probes
• SARS-CoV-2 detection and testing

Identifiers and source

Literature Corpus work

42b80787-1c05-5a10-823c-41b06fd5ed0c

DOI

10.1101/2025.09.21.677611