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Article

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants.

Genome medicine - 14 Oct 2021

Yi Chunyan, Sun Xiaoyu, Lin Yixiao, Gu Chenjian, Ding Longfei, Lu Xiao, Yang Zhuo, Zhang Yaguang, Ma Liyan, Gu Wangpeng, Qu Aidong, Zhou Xu, Li Xiuling, Xu Jianqing, Ling Zhiyang, Xie Youhua, Lu Hongzhou, Sun Bing

Abstract excerpt

BACKGROUND: The receptor-binding domain (RBD) variants of SARS-CoV-2 could impair antibody-mediated neutralization of the virus by host immunity; thus, prospective surveillance of antibody escape mutants and understanding the evolution of RBD are urgently needed. METHODS: Using the single B cell cloning technology, we isolated and characterized 93 RBD-specific antibodies from the memory B cells of four COVID-19...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34649620
DOI: 10.1186/s13073-021-00985-w
PMCID: PMC8515915

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