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Article

Structural characterization and mutational assessment of podocin - a novel drug target to nephrotic syndrome - an in silico approach.

Interdisciplinary sciences, computational life sciences - 1 Mar 2014

Tabassum Asra, Rajeshwari Tadigadapa, Soni Nidhi, Raju D S B, Yadav Mukesh, Nayarisseri Anuraj, Jahan Parveen

Abstract excerpt

Non-synonymous single nucleotide changes (nSNC) are coding variants that introduce amino acid changes in their corresponding proteins. They can affect protein function; they are believed to have the largest impact on human health compared with SNCs in other regions of the genome. Such a sequence alteration directly affects their structural stability through conformational changes. Presence of these conformational...

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PMID: 24464702
DOI: 10.1007/s12539-014-0190-4

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