Enhancing AlphaFold-Multimer-based Protein Complex Structure Prediction with MULTICOM in CASP15

Abstract excerpt

<title>Abstract</title> <p>AlphaFold-Multimer has emerged as the state-of-the-art tool for predicting the quaternary structure of protein complexes (assemblies or multimers) since its release in 2021. To further enhance the AlphaFold-Multimer-based complex structure prediction, we developed a new quaternary structure prediction system (MULTICOM) to improve the input fed to AlphaFold-Multimer and evaluate and refi...

Topics

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• Alzheimer's disease research and treatments
• Amino Acids
• Bioinformatics and Genomic Networks
• Molecular Dynamics Simulation
• Mutation
• Protein Conformation
• Proteins
• RNA

Identifiers and source

Literature Corpus work

65106e6b-f015-544f-bf34-c09ed412cd95

DOI

10.21203/rs.3.rs-2963209/v1