Article

Rapid and Reliable Structural Modeling of Adaptive Immune Receptors Using an Optimized AlphaFold3 workflow

2025-12-19

Abstract excerpt

AlphaFold (AF), a deep-learning based protein modelling approach, has revolutionized structural biology by generally achieving near-experimental accuracy in protein structure prediction. An impactful application of AF is the modelling of antibodies (Abs) and T-cell receptors (TCRs), key mediators of cellular immunity, whose structural specificity underlies responses in cancer, infection, and autoimmune diseases. I...

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Literature Corpus work: 1ea496d9-3e3a-5dee-b86f-4748a42946ce
DOI: 10.64898/2025.12.19.695451

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