Article

MHC class I chain-related genes B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells

2024-01-25

Abstract excerpt

Natural killer group 2 member D ligands (NKG2DLs) are expressed as stress response proteins in cancer cells. NKG2DLs induce immune cell activation or tumor escape responses, depending on their expression. Human pancreatic cancer cells, PANC-1, express membrane MHC class I chain-related genes A/B (mMICA/B), whereas soluble MICB (sMICB) is detected in the culture supernatant. We hypothesized that sMICB saturates NKG...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6502bd4d-38a8-5699-bf15-083344eb3582
DOI: 10.21203/rs.3.rs-3889555/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MHC class I chain-related genes B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cellsDOI 10.21203/rs.3.rs-3889555/v1Read

MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cellsSemantic proximity Read

NKG2D and MICA/B shedding: a ‘tag game’ between NK cells and malignant cellsSemantic proximity Read

MHC class I chain-related A: Polymorphism, regulation and therapeutic value in cancer.Semantic proximity Read

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.Semantic proximity Read

Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.Semantic proximity Read

Leveraging NKG2D Ligands in Immuno-OncologySemantic proximity Read

NKG2D Ligands–Critical Targets for Cancer Immune Escape and TherapySemantic proximity Read

Human NKG2D-ligands: cell biology strategies to ensure immune recognitionSemantic proximity Read

Membrane-bound versus soluble major histocompatibility complex Class I-related chain A and major histocompatibility complex Class I-related chain B differential expression: Mechanisms of tumor eradication versus evasion and current drug development strategies.Semantic proximity Read

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read

An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding.Semantic proximity Read

Regulation of NKG2D Stress Ligands and Its Relevance in Cancer ProgressionSemantic proximity Read