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Article

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.

Cancer research - 15 Jan 2010

Ashiru Omodele, Boutet Philippe, Fernández-Messina Lola, Agüera-González Sonia, Skepper Jeremy N, Valés-Gómez Mar, Reyburn Hugh T

Abstract excerpt

The MHC class I-related chain (MIC) A and MICB ligands for the activating receptor NKG2D can be shed from tumor cells, and the presence of these soluble molecules in sera is related with compromised immune response and progression of disease. Recently, thiol disulphide isomerases and members of t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20068167
DOI: 10.1158/0008-5472.CAN-09-1688
PMCID: PMC2817492

Genes

MICA
MICB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20068167-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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