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Unlocking the potential of circular RNA vaccines: a bioinformatics and computational biology perspective

19 Mar 2025

Abstract excerpt

Bioinformatics has significantly advanced RNA-based therapeutics, particularly circular RNAs (circRNAs), which outperform mRNA vaccines, by offering superior stability, sustained expression, and enhanced immunogenicity due to their covalently closed structure. This review highlights how bioinformatics and computational biology optimise circRNA vaccine design, elucidates internal ribosome entry sites (IRES)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40112741
DOI: 10.1016/j.ebiom.2025.105638

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