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Article

Post-transcriptional regulation via alternative polyadenylation and piRNA shapes macrophage responses in psoriasis.

Frontiers in immunology - 1 Jan 2026

Lin Benfan, Du Xiwang, Lu Leihong, Wang Zongshan, Zhao Yan, Feng Yue, Liu Liqian

Abstract excerpt

Background: Post-transcriptional regulatory mechanisms underlying autoimmune diseases remain poorly understood. Here, we employed integrated multi-omics approaches to systematically dissect the role of alternative polyadenylation (APA) and piRNA-mediated regulation in psoriasis pathogenesis. Methods: We performed transcriptome-wide association studies (TWAS) combined with Mendelian randomization to identify...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42564021
DOI: 10.3389/fimmu.2026.1760348
PMCID: PMC13441757

Genes

TDRKH
IL1B
CD80
CD86
IL23A
IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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