Article

Exploring genetic variability in FOXE1 through in silico approaches: new insights on UTR variants

2026-02-09

Abstract excerpt

<title>Abstract</title> <p> The <italic>FOXE1</italic> gene is a transcription factor critical for thyroid development and function, and has been associated with thyroid disorders and other phenotypic traits like cancer and orofacial clefts. This study explores the genetic variability in <italic>FOXE1</italic> , focusing on non-synonymous single nucleotide variants (nsSNVs) and untranslated region (UTR) vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64aaf727-6cb5-54df-b0ea-c668e9ba4b56
DOI: 10.21203/rs.3.rs-7980581/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring genetic variability in FOXE1 through in silico approaches: new insights on UTR variantsDOI 10.21203/rs.3.rs-7980581/v1Read

Regulatory features aid interpretation of 3’UTR VariantsSemantic proximity Read

utR.annotation: a tool for annotating genomic variants that could influence post-transcriptional regulationSemantic proximity Read

Novel FOXE1 mutation associated with the rare Bamforth-Lazarus syndrome in an Omani familySemantic proximity Read

Annotating high-impact 5’untranslated region variants with the UTRannotatorSemantic proximity Read

The role of untranslated region variants in Mendelian disease: a review.Semantic proximity Read

Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5’UTRsSemantic proximity Read

Predicting functional UTR variants by integrating region-specific features.Semantic proximity Read

A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1.Semantic proximity Read

Domain-specific Analysis of BRCA1 Variants Revealed Enrichment of G → T and C → A TransversionsSemantic proximity Read

Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome.Semantic proximity Read

In silico analysis of single nucleotide polymorphisms (SNPs) in human FOXC2 geneSemantic proximity Read

Bioinformatics Analysis of Non-Coding UTR Variants in <i>STAT1</i> Reveals Disruption of miRNA Binding, mRNA Stability, and Oncogenic PotentialSemantic proximity Read