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Chemical Inhibitors of DksA1, a Conserved Bacterial Transcriptional Regulator, Suppressed Quorum Sensing-Mediated Virulence in <i>Pseudomonas aeruginosa</i>

2020-12-11

Abstract excerpt

Pseudomonas aeruginosa is a Gram-negative bacterium of clinical importance. As an opportunistic pathogen, its virulence is dependent on quorum sensing (QS). Stringent response (SR), a conserved mechanism in the bacterial kingdom, is activated under diverse stress conditions including nutrient starvation. DksA1, an RNA polymerase-binding transcriptional regulator, plays a role in P. aeruginosa SR. Our recent study...

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Literature Corpus work
64911121-419f-5cfd-87a5-f569c5102ee7
DOI
10.1101/2020.12.10.420422
Open publication

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Chemical Inhibitors of DksA1, a Conserved Bacterial Transcriptional Regulator, Suppressed Quorum Sensing-Mediated Virulence in <i>Pseudomonas aeruginosa</i>DOI 10.1101/2020.12.10.420422
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