Article

Signature reversion of three disease-associated gene signatures prioritizes cancer drug repurposing candidates

2023-03-12

Abstract excerpt

<h4>Summary</h4> Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease-associated gene signature to identify drugs that may reverse that signature. We assessed the performance and biological relevance of three approaches for constructing disease-associated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 648bddaa-b7da-52ae-acd8-6cd0674cb9a3
DOI: 10.1101/2023.03.10.532074

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Signature reversion of three disease-associated gene signatures prioritizes cancer drug repurposing candidatesDOI 10.1101/2023.03.10.532074Read

Reversal Gene Expression Assessment for Drug Repurposing, a Case Study of GlioblastomaSemantic proximity Read

Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposingSemantic proximity Read

Reversal gene expression assessment for drug repurposing, a case study of glioblastomaSemantic proximity Read

Tumor relapse-free survival prognosis related consistency between cancer tissue and adjacent normal tissue in drug repurposing for solid tumor via connectivity mapSemantic proximity Read

Tumor relapse-free survival prognosis related consistency between cancer tissue and adjacent normal tissue in drug repurposing for solid tumor via connectivity mapSemantic proximity Read

Prioritization of Potential Drugs Through Pathway-Based Drug Repurposing and Network Proximity AnalysisSemantic proximity Read

The Drug Repurposing Encyclopedia (DRE): a web server for systematic drug repurposing across 20 organismsSemantic proximity Read

Dr.Paso: Drug response prediction and analysis system for oncology researchSemantic proximity Read

An Integrated Knowledge Graph and Network Medicine Pipeline for Drug Repurposing: Benchmarking Across Human Diseases and Application to Amyotrophic Lateral SclerosisSemantic proximity Read

Computational repurposing of oncology drugs through off-target drug binding interactions from pharmacological databasesSemantic proximity Read

Personalized Multi-Drug Combinations in Breast Cancer Treatment Using Individual Pattern of Perturbed Gene Expression and Drug SignaturesSemantic proximity Read

Integrative Statistical Inferences for Drug Sensitivity Biomarkers in CancerSemantic proximity Read