Article

Genetically targeted reporter imaging of deep neuronal network in the mammalian brain

2020-04-09

Abstract excerpt

Positron Emission Tomography (PET) allows biomolecular tracking, while PET monitoring of brain networks has been hampered by the lack of a suitable reporter. Here, we describe in vivo brain imaging that takes advantage of bacterial dihydrofolate reductase, ecDHFR, and its unique antagonist, TMP. In mice, peripheral administration of radiofluorinated and fluorescent TMP analogs enabled PET and intravital microscop...

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Literature Corpus work: cc7ea0bb-6b57-592a-94c4-e076fda8ccea
DOI: 10.1101/2020.04.08.032870

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