Diagnostic value of metagenomic next-generation sequencing for bronchoalveolar lavage diagnostics in patients with lower respiratory tract infections

Abstract excerpt

• mNGS identified pathogens in 92.7% of patients suspected of LRTIs, significantly outperforming CMT which only identified pathogens in 58.8% of cases. • The sensitivity, specificity, PPV, and NPV of mNGS were all significantly higher than those of CMT, with mNGS demonstrating a sensitivity of 99.7% compared to 57.1% for CMT. • The study detailed a diverse range of pathogens causing LRTIs, with significant...

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