Article

Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia

2025-05-14

Abstract excerpt

Despite the high efficacy of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL), approximately 10-20% of patients develop drug resistance due to mutations in PML-RARα and other factors. Here, it is demonstrated that inhibiting USP2 with ML364 or silencing USP2 reduces PML-RARα protein levels in both ATRA-sensitive and -resistant APL cells, an effect reversed by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64628228-792a-572d-b955-63c18012f40a
DOI: 10.1101/2025.05.11.653221

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemiaDOI 10.1101/2025.05.11.653221Read

Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cellsSemantic proximity Read

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemiaSemantic proximity Read

PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic LeukemiaSemantic proximity Read

ATRA Resistance in Acute Promyelocytic Leukemia: Mechanisms Unveiled, Therapies ReimaginedSemantic proximity Read

Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.Semantic proximity Read

Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma CellsSemantic proximity Read

Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapiesSemantic proximity Read

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.Semantic proximity Read

Chromatin Perturbation Promotes Susceptibility to Hypomethylating AgentsSemantic proximity Read

Acute promyelocytic leukemia, arsenic, and PML bodiesSemantic proximity Read

ATRA(ouble) in the treatment of acute promyelocytic leukemia.Semantic proximity Read

Tumor suppressor function of Gata2 in acute promyelocytic leukemia.Semantic proximity Read