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Mechanotransduction in Liver Diseases

4 Nov 2019

Abstract excerpt

Chronic liver diseases, such as fibrosis and cancer, lead to a rigid or stiff liver because of perpetual activation of hepatic stellate cells or portal fibroblasts into matrix-producing myofibroblasts. Mechanical forces, as determined by the mechanical properties of extracellular matrix or pressure of circulating blood flow/shear stress, are sensed by mechanoreceptors at the plasma membrane and transmitted into a...

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PMID: 31683318
DOI: 10.1055/s-0039-3399502

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