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Genes Encoding ACE2, TMPRSS2 and Related Proteins Mediating SARS-CoV-2 Viral Entry are Upregulated with Age in Human Cardiomyocytes

2020-07-07

Abstract excerpt

Age is an independent risk factor for adverse outcome in patients following COVID-19 infection. We hypothesised that differential expression of genes encoding proteins proposed to be required for entry of SARS-Cov-2 in aged compared to younger cardiomyocytes might contribute to the susceptibility of older individuals to COVID-19-associated cardiovascular complications. We generated strand-specific RNA-sequencing l...

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Literature Corpus work
31e707e5-2c5f-5e90-8370-57940d6c75f8
DOI
10.1101/2020.07.07.191429
Open publication

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Genes Encoding ACE2, TMPRSS2 and Related Proteins Mediating SARS-CoV-2 Viral Entry are Upregulated with Age in Human CardiomyocytesDOI 10.1101/2020.07.07.191429
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