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A Cross-Species Systems Genetics Framework Identifies Causal Genes in Diabetic Nephropathy

2026-07-01

Abstract excerpt

Diabetic nephropathy (DN) is the leading cause of kidney failure in the developed world, but the genetic architecture of DN susceptibility is not well characterised. Here we apply a systems genetics approach in a mouse model of DN to discover novel QTLs for clinically relevant phenotypes including albuminuria, glomerulosclerosis, and macrophage infiltration. For context and prioritisation, we combined single-cell-...

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Literature Corpus work
63fb203e-fff6-5a3d-a1cf-61364bdebc7a
DOI
10.64898/2026.06.30.735464
Open publication

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A Cross-Species Systems Genetics Framework Identifies Causal Genes in Diabetic NephropathyDOI 10.64898/2026.06.30.735464
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