Article
An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.
Cell systems - 24 Jan 2018
Li Hao, Wang Xu, Rukina Daria, Huang Qingyao, Lin Tao, Sorrentino Vincenzo, Zhang Hongbo, Bou Sleiman Maroun, Arends Danny, McDaid Aaron, Luan Peiling, Ziari Naveed, Velázquez-Villegas Laura A, Gariani Karim, Kutalik Zoltan, Schoonjans Kristina, Radcliffe Richard A, Prins Pjotr, Morgenthaler Stephan, Williams Robert W, Auwerx Johan
Abstract excerpt
Identifying genetic and environmental factors that impact complex traits and common diseases is a high biomedical priority. Here, we developed, validated, and implemented a series of multi-layered systems approaches, including (expression-based) phenome-wide association, transcriptome-/proteome-wide association, and (reverse-) mediation analysis, in an open-access web server (systems-genetics.org) to expedite the...
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