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Article

Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy.

Genome medicine - 11 Dec 2025

Ma Zijian, Hou Qing, Yang Ruixiang, Shi Jinsong, Kan Shuyan, Zheng Chunxia, Zhu Xiaodong, Liu Zhihong, Jiang Song

Abstract excerpt

BACKGROUND: While genome-wide association studies (GWAS) have shown that genetic variants are linked to diabetic nephropathy (DN), the precise gene responsible for influencing risk remains largely unidentified, and the issue of missing heritability persists. This study seeks to identify new pathogenic genes using transcriptome-wide association study (TWAS) analysis in a cohort with renal biopsy-proven DN....

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Identifiers

PMID: 41382137
DOI: 10.1186/s13073-025-01590-x
PMCID: PMC12801672

Genes

GYS1
FOXJ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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