Article

Prime Editing Models the MTARC1 A165T Variant in Human Liver Organoids, Demonstrating Reduced Steatosis, Inflammation, and Fibrosis

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent cause of chronic liver disease. MASLD is a progressive and multifactorial disease marked initially by hepatic steatosis, which can progress to steatohepatitis, fibrosis, cirrhosis, and liver cancer. Genetic factors influence the development, progression, and complications in MASLD, and genome-wide association...

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Literature Corpus work: 63e27116-2d3f-5bb8-b8cc-79bc4a9e0698
DOI: 10.64898/2025.12.23.696200

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