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Generation of an induced pluripotent stem cell (iPSC) line (EXSURGi001-A) from a patient homozygous for the p.Ala165Thr mutation in the MTARC1 gene.

Stem cell research - 1 Oct 2024

Tang Peter, Keshi Eriselda, Wilken Silvana, Wutsdorff Louise, Mougnekabol Julienne, Pratschke Johann, Sauer Igor M, Haep Nils

Abstract excerpt

Metabolic dysfunction-associated fatty liver disease (MAFLD), the leading cause of end-stage liver disease in developed countries, is expected to increase over the next decade. Characterized by hepatic steatosis, MAFLD is commonly studied in animal models. Here, we generated a human induced pluripotent stem cell (iPSC) line from a patient homozygous of the protective MTARC1 gene variant rs2642438:A. This line...

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PMID: 39094505
DOI: 10.1016/j.scr.2024.103516

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