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Similarities and distinctions in the activation of the <i>Candida glabrata</i> Pdr1 regulatory pathway by azole and non-azole drugs

2024-09-19

Abstract excerpt

Incidences of fluconazole (FLC) resistance among Candida glabrata clinical isolates is a growing issue in clinics. The pleiotropic drug response (PDR) network in C . glabrata confers azole resistance and is defined primarily by the Zn 2 Cys 6 zinc cluster-containing transcription factor Pdr1 and target genes such as CDR1 , that encodes an ATP-binding cassette transporter protein thought to act as a FLC efflu...

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Literature Corpus work
63dfb039-4bfc-5d8d-842e-3cce7f8d990a
DOI
10.1101/2024.09.19.613905
Open publication

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Similarities and distinctions in the activation of the <i>Candida glabrata</i> Pdr1 regulatory pathway by azole and non-azole drugsDOI 10.1101/2024.09.19.613905
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