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Copper Acts Synergistically with Fluconazole in <i>Candida glabrata</i> by Compromising Drug Efflux, Sterol Metabolism, and Zinc Homeostasis

2021-12-23

Abstract excerpt

The synergistic combinations of drugs are promising strategies to boost the effectiveness of current antifungals and thus prevent the emergence of resistance. In this work, we show that copper and the antifungal fluconazole act synergistically against Candida glabrata , an opportunistic pathogenic yeast intrinsically tolerant to fluconazole. Analyses of the transcriptomic profile of C. glabrata after the combin...

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Literature Corpus work
42834bd4-b254-550c-90b8-ab886603be5e
DOI
10.1101/2021.12.22.473865
Open publication

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