Article

Discovery of mitophagy inhibitors with therapeutic potential in different familiar Amyotrophic Lateral Sclerosis mutations

2022-07-18

Abstract excerpt

<title>Abstract</title> <p>Mitophagy is the selective degradation of mitochondria by autophagy. It promotes the turnover of mitochondria and prevents the accumulation of dysfunctional mitochondria, which can lead to cellular degeneration. Mitophagy is known to be altered in several pathological conditions, especially in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We have recently demon...

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Literature Corpus work: 63570bc7-3852-56f0-9715-f2b606e08cf7
DOI: 10.21203/rs.3.rs-1746467/v1

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