Article

Targeting membrane fragility in LGMD R2 through pharmacological autophagy induction

2025-07-14

Abstract excerpt

<title>Abstract</title> <p>Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of genetic disorders characterized by progressive weakening of the limb-girdle muscles. Among LGMDs, Limb-girdle muscular dystrophy type R2 (LGMDR2) is a rare condition affecting fewer than 1 in 100,000 individuals caused by mutations in the gene encoding dysferlin. Recent <italic>in vitro</italic> studies have suggested...

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Literature Corpus work: ca5a086d-0f82-51e5-95ff-d8fea234910d
DOI: 10.21203/rs.3.rs-6671973/v1

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