Article

Drug connectivity mapping and functional analysis reveals therapeutic small molecules that differentially modulate myelination

2020-09-08

Abstract excerpt

Oligodendrocytes are the myelin forming cells of the central nervous system (CNS) and are generated from oligodendrocyte progenitor cells (OPCs). Disruption or loss of oligodendrocytes and myelin has devastating effects on CNS function and integrity, which occurs in diverse neurological disorders, including Multiple Sclerosis (MS), Alzheimer’s disease (AD) and neuropsychiatric disorders. Hence, there is a need to...

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Literature Corpus work: 634d0a24-d9f0-5f59-ab75-f50263a9a959
DOI: 10.1101/2020.09.05.284372

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