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Article

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

29 Jun 2018

Abstract excerpt

Objectives To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bipolar disorder (BD) on cultured human neuronal cells (NT2-N) and rat brains, which also has evidence of differential expression in individuals with BD. To use the GES to identify new drugs for BD using Connectivity Map (CMap).Methods: NT2-N (n = 20) cells and rats (n = 8) were treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29956574
DOI: 10.1080/15622975.2018.1492734

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