An Alternative View of Familial Alzheimer’s Disease Genetics

Abstract excerpt

Probabilistic and parsimony-based arguments regarding available genetics data are used to propose that Hardy and Higgin’s amyloid cascade hypothesis is valid but is commonly interpreted too narrowly to support, incorrectly, the primacy of the amyloid beta peptide (Aβ) in driving Alzheimer’s disease pathogenesis. Instead, increased activity of the βCTF (C99) fragment of APP is likely the criti...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Amyloid Precursor Protein Secretases
• Iron
• Mutation
• Presenilin-1

Identifiers and source

Literature Corpus work

633f84f9-ea9e-55b4-8656-55dd53c7d94f

DOI

10.20944/preprints202303.0476.v2