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Article

Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors.

International journal of molecular sciences - 7 Nov 2024

Bagyinszky Eva, An Seong Soo A

Abstract excerpt

Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various genetic factors. In addition to the well-established amyloid precursor protein (APP), Presenilin-1 (PSEN1), Presenilin-2 (PSEN2), and apolipoprotein E (APOE), several other genes such as Sortilin-related receptor 1 (SORL1), Phospholipid-transporting ATPase ABCA7 (ABCA7), Triggering Receptor Expressed on Myeloid Cells 2 (TREM2),...

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Identifiers

PMID: 39596030
DOI: 10.3390/ijms252211959
PMCID: PMC11594089

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