Article
CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype.
Journal for immunotherapy of cancer - 1 Mar 2022
Li Han, Luo Fan, Jiang Xingyu, Zhang Weijing, Xiang Tong, Pan Qiuzhong, Cai Liming, Zhao Jingjing, Weng Desheng, Li Yue, Dai Yuhu, Sun Fengze, Yang Chaopin, Huang Yue, Yang Jieying, Tang Yan, Han Yulong, He Mian, Zhang Yanna, Song Libing, Xia Jian-Chuan
Abstract excerpt
BACKGROUND: Platinum resistance is a major challenge in the clinical treatment of advanced ovarian cancer (OC). Accumulating evidence shows that the tumor-promotive M2 macrophage is linked to the limiting chemotherapy efficacy of multiple malignancies including OC. Circular RNAs (circRNAs) are a novel class of non-coding RNAs which function as the critical regulator in biological process of cancer. However, their...
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