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Article

Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers.

Journal of translational medicine - 6 Aug 2025

De Angelis Maria Teresa, Rizzuto Antonia, Amaddeo Angela, Sagnelli Carlo, Vono Niccolò, Reda Michela, Lise Valentina, Parrillo Luca, De Marco Carmela, Malanga Donatella, Santamaria Gianluca, Viglietto Giuseppe

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) encompasses tumors arising in the colon (CC) and rectum (RC), often treated as a single disease despite emerging evidence of biological divergence. Understanding the molecular differences between CC and RC is critical for improving diagnosis, prognosis, and therapeutic strategies. METHODS: We performed an integrated genomic and transcriptomic analysis of CC and RC data from The...

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Topics

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Share to Chromosomes, Human
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to GATA2 gene

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Source

Open in PubMed Open full text

Identifiers

PMID: 40770356
DOI: 10.1186/s12967-025-06908-2
PMCID: PMC12330160

Genes

ACVR1B
BRAF
C2CD4B
C4BPA
DNAH1
EHD1
GATA2
LTBP4
MYC
NRAS
PIK3CA
SETD1A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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