Article

Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia

2020-02-28

Abstract excerpt

Studies of acute myeloid leukemia rely on DNA sequencing and immunophenotyping by flow cytometry as primary tools for disease characterization. However, leukemia tumor heterogeneity complicates integration of DNA variants and immunophenotypes from separate measurements. Here we introduce DAb-seq, a novel technology for simultaneous capture of DNA genotype and cell surface phenotype from single cells at high throug...

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Literature Corpus work: 62f026b6-a172-54bf-87f8-728da9f82976
DOI: 10.1101/2020.02.26.967133

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