Article

LEO1 loss promotes ER stress-adapted migration and cholesterol dependency in colorectal cancer

2026-05-20

Abstract excerpt

The RNA polymerase-associated factor 1 complex (PAF1C) is an evolutionarily conserved transcription elongation complex that regulates RNA polymerase II-mediated transcription and chromatin modification. LEO1, a core subunit of PAF1C, has been implicated in developmental gene regulation, WNT signaling, and leukemogenesis; however, its role in solid tumor progression remains poorly understood. In this study, we foun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62ecf5a9-a746-56d6-b0a3-86ec4f448600
DOI: 10.64898/2026.05.17.725800

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LEO1 loss promotes ER stress-adapted migration and cholesterol dependency in colorectal cancerDOI 10.64898/2026.05.17.725800Read

High expression of RUNX1 in colorectal cancer subtype accelerates malignancy by inhibiting HMGCRSemantic proximity Read

Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal CancerSemantic proximity Read

ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancerSemantic proximity Read

Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.Semantic proximity Read

ERO1L promotes NSCLC development by modulating cell cycle‐related moleculesSemantic proximity Read

The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategiesSemantic proximity Read

HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1Semantic proximity Read

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-MycSemantic proximity Read

XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesisSemantic proximity Read

Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal CancerSemantic proximity Read

Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathwaysSemantic proximity Read

P1 promoter-driven HNF4α isoforms are specifically repressed by β-catenin signaling in colorectal cancer cellsSemantic proximity Read