Article

Tafazzin knockdown in murine mesenchymal stem cells enhances the tafazzin knockdown mediated elevation in interleukin-10 secretion from murine B lymphocytes

2023-03-02

Abstract excerpt

Barth Syndrome is a rare X-linked genetic disorder caused by mutations in the TAFAZZIN gene. We recently demonstrated that tafazzin (Taz) protein deficiency in murine mesenchymal stems (MSCs) reduces immune function of activated wild type (WT) B lymphocytes. Interleukin-10 (IL-10) is a key anti-inflammatory cytokine capable of exerting immunosuppressive effects on myeloid cells. Here we examined if Taz deficiency...

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Literature Corpus work: 62dfa448-18da-55f7-abd5-8e81ed1114e5
DOI: 10.1101/2023.03.01.530640

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