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Article

Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissues.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Oct 2004

Lu Biao, Kelher Marguerite R, Lee Douglas P, Lewin Tal M, Coleman Rosalind A, Choy Patrick C, Hatch Grant M

Abstract excerpt

Tafazzins, a group of proteins that are defective in patients with Barth syndrome, are produced by alternate splicing of the gene G4.5 or TAZ. RT-PCR and transcription-coupled in vitro translation analysis were undertaken to determine the expression of alternatively spliced TAZ mRNA in mouse tiss...

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Identifiers

PMID: 15499385
DOI: 10.1139/o04-055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15499385-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissues.PMID 15499385Read ↗

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A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosisSemantic proximity Read ↗

Tafazzin deficiency in mouse mesenchymal stem cells promote reprogramming of activated B lymphocytes toward immunosuppressive phenotypes.Semantic proximity Read ↗

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A novel X-linked gene, G4.5. is responsible for Barth syndrome.Semantic proximity Read ↗

Defining functional classes of Barth syndrome mutation in humans.Semantic proximity Read ↗

Tafazzin knockdown in murine mesenchymal stem cells enhances the tafazzin knockdown mediated elevation in interleukin-10 secretion from murine B lymphocytesSemantic proximity Read ↗

Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients.Semantic proximity Read ↗

Only one splice variant of the human TAZ gene encodes a functional protein with a role in cardiolipin metabolism.Semantic proximity Read ↗

Loss of TAFAZZIN leads to perturbation of amino acid metabolism and reduction of collagen synthesisSemantic proximity Read ↗

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