Article
Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissues.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Oct 2004
Lu Biao, Kelher Marguerite R, Lee Douglas P, Lewin Tal M, Coleman Rosalind A, Choy Patrick C, Hatch Grant M
Abstract excerpt
Tafazzins, a group of proteins that are defective in patients with Barth syndrome, are produced by alternate splicing of the gene G4.5 or TAZ. RT-PCR and transcription-coupled in vitro translation analysis were undertaken to determine the expression of alternatively spliced TAZ mRNA in mouse tissues and human cell lines. Only two tafazzin transcripts, both lacking exon 5, were expressed in murine tissues, whereas...
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