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Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

13 Jan 2014

Abstract excerpt

Bone marrow mesenchymal stem cells (BMMSCs) are capable of differentiating into multiple cell types and regulating immune cell response. However, the mechanisms that govern the immunomodulatory properties of BMMSCs are still not fully elucidated. Here we show that telomerase-deficient BMMSCs lose their capacity to inhibit T cells and ameliorate the disease phenotype in systemic sclerosis mice. Restoration of...

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PMID: 24401839
DOI: 10.1002/emmm.201303000

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