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Article

Tafazzin deficiency in mouse mesenchymal stem cells promote reprogramming of activated B lymphocytes toward immunosuppressive phenotypes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2022

Zegallai Hana M, Abu-El-Rub Ejlal, Olayinka-Adefemi Folayemi, Cole Laura K, Sparagna Genevieve C, Marshall Aaron J, Hatch Grant M

Abstract excerpt

Barth Syndrome (BTHS) is a rare X-linked genetic disorder caused by mutation in the TAFAZZIN gene. Tafazzin (Taz) deficiency in BTHS patients results in an increased risk of infections. Mesenchymal stem cells (MSCs) are well known for their immune-inhibitory function. We examined how Taz-deficiency in murine MSCs impact their ability to modulate the function of lipopolysaccharide (LPS)-activated wild type (WT) B...

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PMID: 35816277
DOI: 10.1096/fj.202200145R

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