Article

Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective?

2017-02-28

Abstract excerpt

Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells. However, whether they contribute to disease pathogenesis or have protective functions is unclear. Here, we discuss how tertiary lymphoid or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62bc2137-f5eb-57bc-8487-2c50363eee43
DOI: 10.12688/f1000research.10595.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective?DOI 10.12688/f1000research.10595.1Read

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling.Semantic proximity Read

The roles of tertiary lymphoid structures in chronic diseasesSemantic proximity Read

Role of Fibroblast‐Immune Crosstalk in Kidney, Lung, and Skin Tertiary Lymphoid StructuresSemantic proximity Read

Innate Lymphoid Cells in Tissue Homeostasis and Disease PathogenesisSemantic proximity Read

Pathophysiological mechanisms of autoimmunity.Semantic proximity Read

NK Cells in Autoimmune Diseases: Protective or Pathogenic?Semantic proximity Read

Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancerSemantic proximity Read

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupusSemantic proximity Read

Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune diseaseSemantic proximity Read

Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategiesSemantic proximity Read

The balance of power: innate lymphoid cells in tissue inflammation and repairSemantic proximity Read

Tertiary lymphoid structures in cancerSemantic proximity Read