Article

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug Screening

2025-07-28

Abstract excerpt

<title>Abstract</title> <p>Introduction: Osteogenesis Imperfecta (OI) is a rare genetic disorder of connective tissue, primarily caused by mutations in the COL1A1 or COL1A2 genes. Research is hampered by the limitations of primary patient-derived cells, which are obtained through invasive methods and have finite proliferative capacity and high variability. While induced pluripotent stem cell (iPSC) models exist,...

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Literature Corpus work: 790e5157-87c5-570b-bb03-7f2aa68800c9
DOI: 10.21203/rs.3.rs-7135025/v1

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