Article

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug Screening

2025-06-16

Abstract excerpt

<h4>Introduction</h4> Osteogenesis Imperfecta (OI) is a rare genetic disorder of connective tissue, primarily caused by mutations in the COL1A1 or COL1A2 genes. Research is hampered by the limitations of primary patient-derived cells, which are obtained through invasive methods and have finite proliferative capacity and high variability. While induced pluripotent stem cell (iPSC) models exist, direct differentiat...

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Literature Corpus work: e5964a7b-3ee0-52e8-a0cf-d97c8b4739c3
DOI: 10.1101/2025.06.11.659155

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