Article

Identification of High risk nsSNPs in Human <i>TP53</i> Gene Associated with Li–Fraumeni Syndrome: An <i>In Silico</i> Analysis Approach

2020-12-06

Abstract excerpt

<h4>Background</h4> Li–Fraumeni syndrome (LFS) is a cancer–prone conditions caused by a germline mutation of the TP53 gene on chromosome 17p13.1. It has an autosomal dominant pattern of inheritance with high penetrance. <h4>Purpose</h4> The aim of this study is to identify the high-risk pathogenic nsSNPs in PT53 gene that could be involved in the pathogenesis of Li–Fraumeni syndrome. <h4>Methods</h4> The nsSN...

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Literature Corpus work: 629ba881-69f7-5737-8c4c-e5d9aa3aa5eb
DOI: 10.1101/2020.12.04.411835

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