Article

<i>TP53</i>Variant Clusters Stratify the Li-Fraumeni Spectrum and Reveal an Osteosarcoma-Prone Subgroup

2024-01-07

Abstract excerpt

<h4>ABSTRACT</h4> Li-Fraumeni syndrome (LFS) has recently been redefined as a ‘spectrum’ cancer predisposition disorder to reflect its broad phenotypic heterogeneity. The wide functional gradient associated with different TP53 variants is thought to contribute to LFS heterogeneity, although it is still poorly understood and there is an unmet clinical need for risk stratification strategies. Leveraging p53 mutagene...

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Literature Corpus work: 66578e31-95e6-5b55-ab12-7751fbd71647
DOI: 10.1101/2024.01.06.23300162

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