Article

Clinical and Genetic Analysis of Li-Fraumeni Syndrome with Novel TP53 Mutations

2024-01-03

Abstract excerpt

<title>Abstract</title> <p>Objective Mutations in the <italic>TP53</italic> gene can cause Li-Fraumeni syndrome (LFS), an autosomal dominant genetic syndrome that increases susceptibility to various tumors. This study aims to explore the clinical and pathological features as well as the genetic characteristics of LFS to provide a theoretical basis for genetic counseling in affected families. Methods We conducte...

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Literature Corpus work: 23933fb5-87e7-56cc-b269-d669d63859bc
DOI: 10.21203/rs.3.rs-3811434/v1

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