Article

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

2020-09-01

Abstract excerpt

<h4>Summary</h4> The global emergence of Zika virus (ZIKV) in the last decade revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects such as microcephaly. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards highe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 628d3d1c-16b9-5f7b-babf-ade7ce697c04
DOI: 10.1101/2020.09.01.277673

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineageDOI 10.1101/2020.09.01.277673Read

Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strainsSemantic proximity Read

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaquesSemantic proximity Read

Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicitySemantic proximity Read

A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.Semantic proximity Read

An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.Semantic proximity Read

African and Asian Zika Virus Isolates Display Phenotypic Differences Both In Vitro and In VivoSemantic proximity Read

Zika Virus Exhibits Lineage-Specific Phenotypes in Cell Culture, in Aedes aegypti Mosquitoes, and in an Embryo Model.Semantic proximity Read

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virusSemantic proximity Read

Differential virulence between Asian and African lineages of Zika virusSemantic proximity Read

Asian Zika virus can acquire generic African-lineage mutations during in utero infection.Semantic proximity Read

American Strain of Zika Virus Causes More Severe Microcephaly Than an Old Asian Strain in Neonatal MiceSemantic proximity Read

Contributions of Genetic Evolution to Zika Virus EmergenceSemantic proximity Read