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Zika Virus Exhibits Lineage-Specific Phenotypes in Cell Culture, in Aedes aegypti Mosquitoes, and in an Embryo Model.

Viruses - 16 Dec 2017

Willard Katherine A, Demakovsky Leah, Tesla Blanka, Goodfellow Forrest T, Stice Steven L, Murdock Courtney C, Brindley Melinda A

Abstract excerpt

Zika virus (ZIKV) has quietly circulated in Africa and Southeast Asia for the past 65 years. However, the recent ZIKV epidemic in the Americas propelled this mosquito-borne virus to the forefront of flavivirus research. Based on historical evidence, ZIKV infections in Africa were sporadic and caused mild symptoms such as fever, skin rash, and general malaise. In contrast, recent Asian-lineage ZIKV infections in...

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PMID: 29258204
DOI: 10.3390/v9120383
PMCID: PMC5744157

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