Article

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

2020-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Following the Zika virus (ZIKV) outbreak in the Americas, ZIKV was causally associated with microcephaly and a range of neurological and developmental symptoms, termed congenital Zika syndrome (CZS). The isolates responsible for this outbreak belonged to the Asian lineage of ZIKV. However, in-vitro and in-vivo studies assessing the pathogenesis of African-lineage ZIKV demonstrated that African-l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b584fff0-32aa-5295-99e2-659719aa217e
DOI: 10.1101/2020.11.30.405670

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaquesDOI 10.1101/2020.11.30.405670Read

African-Lineage Zika Virus Replication Dynamics and Maternal-Fetal Interface Infection in Pregnant Rhesus MacaquesSemantic proximity Read

Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques ( <i>Macaca mulatta</i> ) with an African-lineage Zika virusSemantic proximity Read

A rhesus macaque model of Asian-lineage Zika virus infectionSemantic proximity Read

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virusSemantic proximity Read

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virusSemantic proximity Read

Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) modelSemantic proximity Read

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virusSemantic proximity Read

Maternal-fetal transmission of the zika virus: An intriguing interplaySemantic proximity Read

Heterologous Protection against Asian Zika Virus Challenge in Rhesus MacaquesSemantic proximity Read

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectorsSemantic proximity Read

Differential virulence between Asian and African lineages of Zika virusSemantic proximity Read

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virusSemantic proximity Read