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M2 Macrophage-Based Classification Identifies DOK3 as a Driver of Pro-tumoral Polarization and Migration in Glioblastoma

2025-09-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>IDH-wildtype glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by limited therapeutic options and dismal prognosis. Among the components of the immunosuppressive tumor microenvironment (TME), M2-polarized macrophages are pivotal mediators of tumor progression, yet the molecular mechanisms underlying their polarization and pro-tumoral f...

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Literature Corpus work
6251328f-f97b-533b-903c-9ffa0a504ef4
DOI
10.21203/rs.3.rs-7534936/v1
Open publication

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